MAPT and Cognitive impairment: The etiologies of cognitive impairment or dementia can be divided into vascular cognitive impairment, neurodegenerative disorders associated with the prion-like spreading, deposition of misfolded proteins (such as amyloid-beta, alfa-synuclein, hyperphosphorylated tau, transactive response DNA-binding protein 43 (TDP-43) or Lewy body) or frontotemporal dementia (Soto and Satani, 2011; Twohig and Nielsen, 2019; D’errico and Meyer-Luehmann, 2020; Hall et al., 2020; Jo et al., 2020).