Cone neurite sprouting has been described for humans with retinitis pigmentosa (Li et al., 1995; Milam and Li, 1996) and age-related macular degeneration (AMD) (Pow and Sullivan, 2007) as well as for two mouse models: rd1 (Fei, 2002; Lin et al., 2009) and Cav1.4 knock-out mice (Raven et al., 2008; Zabouri and Haverkamp, 2013). The gene discussed is PDE6B; the disease is age-related macular degeneration.