In addition, the administration of pan Cx43 blocker and Cx43 hemichannel inhibitors in the ALS mouse model can alleviate the neuronal toxicity (Takeuchi et al., 2011; Almad et al., 2016), suggesting that targeting Cx43 hemichannel function is a potential ALS treatment strategy. The gene discussed is GJA1; the disease is amyotrophic lateral sclerosis.