MAPT and Senile plaques: Some selective biomarkers in the CSF were shown to have excellent diagnostic accuracy (Olsson et al., 2016) such as Aβ42, which is related to the extracellular senile plaques (Ashton et al., 2018), total tau protein (T-tau), which reflects the level of neuronal damage (Scholl et al., 2019), and phosphorylated tau protein on threonine 181 (P-tau181), which correlates with tangle pathology (Hampel et al., 2010).