PRKN and Parkinson disease: To address the potential mechanisms of NBP by modulating mitochondrial dynamics in the A53T-α-synuclein PD mouse model, the expressions of mitochondrial fission protein (dynamin-related protein-1, Drp1) and mitochondrial fusion protein (mitofusin 1, Mfn1) and the indicators of autophagy (LC3) and mitophagy (Parkin) were detected by Western blotting analysis.