Genetic analysis included Angelman syndrome testing (15q11-q13 methylation pattern and UBE3A sequencing), karyotype, fragile X syndrome testing, subtelomeric MLPA (SALSA MLPA P070, MRC Holland), and 60K array Comparative Genomic Hybridization (aCGH) (Agilent Technologies) with normal results. Here, UBE3A is linked to fragile X syndrome.