As shown in Figure 3(Fig. 3), T2D decreases the production of eNOS-derived NO in osteocytes and, therefore, decreases osteocytes' capabilities in detecting and initiating the bone remodeling signals (step 1) (Collin-Osdoby et al., 2000[31]; Bakker et al., 2009[14]). Here, NOS3 is linked to type 2 diabetes mellitus.