In T2D, within the bone cells, the expression and activity of the endothelial NOS (eNOS) are decreased (Kalyanaraman et al., 2018[80]), while that of the inducible isoform, iNOS, is increased (MacPherson et al., 1999;[96] Bhatta et al., 2016[15]). Here, NOS3 is linked to type 2 diabetes mellitus.