The sufficient-protein levels and timely Nrf2-activation is pivotal for cells to antagonize stress insults, where the inadequate level of Nrf2 has been implicated as pathogenic-executive players for myriad inflammatory and stress-related disorders (Unoki et al., 2020[18]; Dodson et al., 2019[6]; Silva-Islas and Maldonado, 2018[16]). This evidence concerns the gene NFE2L2 and stress-related disorder.