The various molecular mechanism through which 6-Shogaol protects against renal IR injury is by attenuating the canonical NF-κB pathway and activation of heme oxygenase (HO)-1 synthesis via p38 MAPK activation that may correlate clinical evident and efficacy of 6 shogaol in urolithiasis animal models (Han et al., 2019). The gene discussed is NFKB1; the disease is urolithiasis.