Shen et al. (2006) found that the growth of prostate cancer in DARC-deficient mice was more aggressive, compared to wild-type mice, due to the unblocked angiogenesis of tumor cells. However, this link between DARC and malignancy has been debated by one study (Elson et al., 2011). Here, ACKR1 is linked to Familial prostate cancer.