EP300 and small cell lung carcinoma: The recurrently observed inactivating gene alterations of CREBBP/EP300 (Peifer et al., 2012; George et al., 2015; Rudin et al., 2012) in SCLC, as well as in EGFR-mutant LUAD tumors that subsequently undergo TKI-induced SCLC transformation (Offin et al., 2019), suggest that a global or local increase in H3K27ac is incompatible with SCLC.