Although A-485 treatment did not rescue the ERK-mediated suppression of NE factors in H2107 and H524 cells even when combined with MSK inhibition (Figure 4—figure supplement 1a) or with HES1 knockout (Figure 4—figure supplement 1c), these results collectively suggest that constitutively activated ERK suppresses NETFs partly through MSK but mostly via reconfiguration of chromatin structure by CBP/p300 in a subset of SCLC. The gene discussed is HES1; the disease is small cell lung carcinoma.