Prominently increased H3K27ac after mutant oncogene induction in SCLC was of interest as over 90% of H3K27ac in cells is dependent on two histone acetyltransferases (HATs) – cAMP-response-element-binding protein (CREB)-binding protein (CBP)/CREBBP and its homologous p300/EP300 (Jin et al., 2011) – which are recurrently inactivated by mutations in SCLC (Peifer et al., 2012; George et al., 2015; Rudin et al., 2012). This evidence concerns the gene CREBBP and small cell lung carcinoma.