Based on our findings that ERK, MSK/RSK, and CBP/p300 play critical roles in the regulation of NETFs in SCLC cell lines, we treated EGFR/TP53/RB1 triple-mutant H1975 cells with inhibitors for EGFR, ERK, MSK/RSK, and/or CBP/p300 to inhibit effectors that suppress NE differentiation with the anticipation that it would eventually cause histological transformation into SCLC. This evidence concerns the gene RB1 and small cell lung carcinoma.