LAIR-2 can be found in vivo in the urine from pregnant women and in fluids such as synovial fluid of rheumatoid arthritis (RA) and osteoarthritis (OA) patients and the circulation of patients with autoimmune thyroid disease ( Lebbink et al., 2008; Olde Nordkamp et al., 2011; Simone et al., 2013). The gene discussed is LAIR2; the disease is rheumatoid arthritis.