In addition, CD123 is a significant factor to control proliferation, growth, and differentiation of AML cell via the activation of many signal pathways such as JAK/STAT (Shi et al., 2019; Bulaeva et al., 2020; Lane, 2020; Sugita & Guzman, 2020). The gene discussed is IL3RA; the disease is acute myeloid leukemia.