A univariate Cox regression analysis of TP73 expression together with patient age, tumor grade, gender, IDH mutation status, 1p/19q codeletion status, MGMT promoter methylation status, and histopathological phenotype, in 3 WHO grade II/III glioma datasets, found that TP73 expression, tumor grade, IDH mutation status, 1p/19q codeletion status and histopathological phenotype always showed a significant correlation with survival prognosis (p < 0.05), and could be performed as independent prognostic factors (Figure 3A, Figure S3A). This evidence concerns the gene IDH1 and central nervous system cancer.