Similarly, MMPs are proteinase enzymes that proteolytically digest different protein substrates, including other proteinases, growth factors, cell‐surface receptors, and many components of the ECM. MMP1 is upregulated in various cancers and has been reported to be associated with tumor invasion and metastasis,42 which is significantly negatively correlated with cancer survival.43 The gene discussed is MMP1; the disease is cancer.