As expected, all signatures were prominently survival‐related in pan‐cancer, and the five‐gene signature consisting of ADAM12, MMP1, SERPINE1, PLOD3, and P4HA3 was survival‐related in the most types of cancer under different p threshold values (p < 0.05, 29 types of cancer; p < 0.01, 24 types; p < 0.005, 24 types; mean C_index = 0.65, mean AUC value = 0.68). The gene discussed is PLOD3; the disease is cancer.