In addition, the increases in neuronal apoptosis within the CA1 area and depression‐like behaviours induced by CUMS were also prevented by an up‐regulation of miR‐211‐5p, suggesting that the CUMS‐induced miR‐211‐5p deficits may result in depression via elevating Dyrk1A levels. This evidence concerns the gene DYRK1A and depressive disorder.