PTPRN and type 1 diabetes mellitus: In another study, the inverse association between simultaneous positivity for antibodies against islet cell cytoplasmic antigens (ICA), glutamic acid decarboxylase enzyme (GAD), and tyrosine phosphatase-like transmembrane glycoprotein (IA2) and metabolic syndrome and its components present in LADA patients might imply that LADA patients are phenotypically closer to T1DM patients [27].