SGCB and coronary artery disorder: Similarly, in a recent review enrolling more than 1000 studies [30], Tejero et al. found that dysregulated production of reactive oxygen species (ROS) or reactive nitrogen species (RNS), such as NO, lead to oxidative stress and in turn induced the onset and development of CAD, and they interpreted particularly the related mechanisms of lots of signaling molecules such as Tyr657, heme-depleted sGC and NOXs.