Kim et al. reported that PirB and its human ortholog LilrB2 (leukocyte immunoglobulin-like receptor B2) are receptors for soluble β-amyloid (Aβ) oligomers—key mediators for cognitive malfunction in Alzheimer disease (AD) [31]. This evidence concerns the gene LILRB2 and early-onset autosomal dominant Alzheimer disease.