Meanwhile, PIK3R3 overexpression partly rescued the cell proliferation and blocked the cell apoptosis, which were mediated by miR-513b-5p mimic in the HepG2, Huh-7, and HCCLM3 cells (Figure 6C–6F, Supplementary Figure 5), implying that PIK3R3 is involved in miR-513b-5p-inhibited autophagy liver cancer cells. The gene discussed is PIK3R3; the disease is liver cancer.