According to the previous study, several upstream factors, including long non-coding RNA FTX [25], long non-coding RNA UCA1 [26], long non-coding RNA LINC00861 [27], long non-coding RNA AZIN1-AS1 [13], circular RNA G004213 [28], and circular RNA circ_LARP4 [29], in the modulation of cancer progression, such as pancreatic cancer, osteosarcoma, cervical cancer, non-small cell lung cancer, and ovarian cancer. This evidence concerns the gene UCA1 and familial pancreatic carcinoma.