In our hospital, a 27-year-old male was diagnosed with AML, having t(9;11)(p21.3;q23.3); KMT2A-MLLT3, accompanied by Wilms' tumor 1 (WT1, NM_024426.6:exon7:c.1109G>C:p.Arg370Pro) and tet methylcytosine dioxygenase 2 (TET2, NM_001127208.3:exon11:c.5530G>A:p.Asp1844Asn) variants, without abnormal WT1 mRNA expression. This evidence concerns the gene WT1 and acute myeloid leukemia.