TNF and infection: Infection with ZIKV-Brazil or ZIKV-FP as compared to ZIKV-SG was typically characterized by higher values of variables contributing to PC1, such as throat viremia, TNFα or the percentage of DCs and monocytes Figure 7C. This suggests that as opposed to ZIKV-SG, infection with the ZIKV-Brazil and ZIKV-FP isolates induces higher throat viremia and a higher inflammatory state.