Arterial stiffness has been appeared in the early stages of chronic kidney disease (CKD), and might be increased in ESRD patients due to deterioration of renal function, the deposit of abnormal product derived from proteins or lipids, the reduction of advanced glycation end products (AGEs), alteration of calcium and phosphate metabolism, low serum albumin levels, and high C-reactive protein serum levels [14,15]. The gene discussed is ALB; the disease is chronic kidney disease.