TCGA database mining indicated that the expression level of 12‐LOX (ALOX12) exhibited no significant correlation with the parameters of gender, age, smoking and alcohol consumption habit of ESCC patients, whereas a strong correlation was noted with histological type (http://ualcan.path.uab.edu/cgi‐bin/TCGAExResultNew2.pl?genenam=ALOX12&ctype=ESCA). The gene discussed is ALOX12; the disease is esophageal squamous cell carcinoma.