The phosphatidylinositol 3‐kinase (PI3K)/AKT/mTOR pathway (mammalian target of rapamycin) is activated in most human cancers,17, 18, 19 which plays an important role in numerous cellular functions including metabolism, proliferation, adhesion, migration, invasion, survival and angiogenesis.20, 21. This evidence concerns the gene AKT1 and cancer.