Natural mutations in AQP2 are responsible for nephrogenic diabetes insipidus (NDI), a condition where affected individuals are unable to concentrate ultrafiltrate, thus producing large urinary volumes, with corollary health problems including polydipsia, polyuria, dehydration and possibly death (Bichet, 2020; Bockenhauer & Bichet, 2015). This evidence concerns the gene AQP2 and nephrogenic diabetes insipidus.