Moreover, qRT‐PCR (Figure 1C), Western blot analysis (Figure 1D, E) and immunohistochemical analysis (Figure 1F, G) results also revealed that the expression of SENP1 was significantly decreased in hippocampus of mice with IH treatment compared to that with normoxia treatment, suggesting that SENP1 in hippocampus may play an essential role in IH impairment. This evidence concerns the gene SENP1 and isolated hemihyperplasia.