While OC use was not associated with EO-CRC risk in our study (and HRT was not assessed due to small numbers in this largely premenopausal sample), the reduced risk associated with parity may be partly explained by changes in endogenous sex hormones (e.g., estrogen, prolactin) during pregnancy [91] and warrants additional investigation according to menopausal status. Here, PRL is linked to colorectal carcinoma.