CD8A and melanoma: The two targeted antigens, Melan-A and MELOE-1, shared common features regarding their frequent expression in melanoma tumors, the recognition of two immunodominant HLA-A2 epitopes by melanoma-specific CD8 T cells involved in melanoma immuno-surveillance [3, 4], and of vast and diverse specific TCR repertoires in all HLA-A2 melanoma patients [5–7].