Given the specificity of PKP2 cardiomyopathy for the ARVC phenotype in particular, we hypothesized that of the ACM probands and PKP2 missense variants in the Clinical Genetic Testing Cohort (N = 40, Fig. 2, solid blue box), those with ARVC-specific diagnosis would be enriched in predicted windows (N = 16). Here, PKP2 is linked to arrhythmogenic right ventricular cardiomyopathy.