To investigate whether the inclusion of probands with any ACM-associated phenotype (not only ARVC) was adequate to detect an effect of PKP2 truncating variants in ACM, we performed the same analysis using data from the ACM genetic testing cohort (Supplementary Table 1 inclusive of, but not exclusive to ARVC; Fig. 1, N = 4,941). The gene discussed is PKP2; the disease is arrhythmogenic right ventricular cardiomyopathy.