MAPT and Alzheimer disease: In the whole sample, longitudinal plasma p-tau181 showed significant associations with concurrent changes of multiple AD-related hallmarks including CSF p-tau, t-tau, Aβ-PET, FDG-PET, hippocampal volume, middle temporal volume, ventricular volume, whole brain volume, MMSE, CDR-SB, ADAS-Cog, memory composite, EF composite, language composite, and visuospatial composite (Table 3).