Further analysis of gene enrichment of the transcriptional misregulation in cancer signaling pathway revealed TCF3 (transcription factor 3), CDK14 (cyclin-dependent kinase 14), JUP (junction plakoglobin), SPINT1 (serine peptidase inhibitor, Kunitz type 1), CDKN1A (cyclin-dependent kinase inhibitor 1A, p21), and IGF1 (insulin-like growth factor 1) as downstream target genes that influence the phenotype of tumor cells (Fig. 3I, Fig. S3A). Here, SPINT1 is linked to cancer.