TGFB1 and chronic myelogenous leukemia, BCR-ABL1 positive: Pathway analysis on these pSTAT3-Y705-bound sites revealed target genes enriched in glycolysis, carbohydrate metabolism, pentose phosphate pathway, AMPK signaling and cytokine-cytokine interaction in the CML-TKI LSK, while hedgehog signaling, Wnt/β-catenin signaling and TGFβ signaling are enriched in the CML LSK (Fig. 3A), corroborating the enriched pathways observed in the transcriptomic analysis.