MSH2 and colorectal carcinoma: The MSH2 variant is correlated with the highest risk of developing many cancers, except CRC, with cumulative cancer incidences of 48.9% for EC, 17.4% for ovarian cancer, 18.7% (females) and 17.6% (males) for ureter and kidney cancers, and 23.8% for prostate cancer [20].