Another study revealed that the piR-54265/PIWIL2 complex could recruit STAT3 and P-SRC via the PAZ domain of PIWIL2, form the PIWIL2/STAT3/P-SRC complex, promote STAT3 phosphorylation and signaling pathway activation, and finally contribute to colorectal tumorigenesis [19]. Here, STAT3 is linked to medical procedure.