RALA and neoplasm: Despite the contradictory associations of RALA and RALB with TNBC cell growth in vitro or in vivo, we demonstrate that BQU57, a small molecule inhibitor of both RAL isoforms, reduces TNBC cell viability, increases sensitivity to chemotherapy and hinders orthotopic tumor growth and metastasis of a TNBC cell line and patient-derived xenograft model in vivo.