In the univariate analysis, PS ≥ 2, hypertension, heart disease, upper GC, CEA ≥ 5, CA19-9 ≥ 37, albumin< 3.5, CRP ≥ 0.5, pT4, pN+, positive lymphatic invasion, positive venous invasion, Neut ≥ 3690, Lymp < 1860, Plt ≥ 27.2 × 104, and SII ≥ 395 correlated with poor OS. The gene discussed is CEACAM5; the disease is heart disorder.