We found that a 60% downregulation of S100A4 is sufficient to strongly decrease the levels of mTOR and SQSTM1/p62 proteins in fibroblasts from ALS patients (Fig. 2a, b), as well as the expression of p-NF-κB in C9orf72 cells (Fig. 2b), with respect to scramble silenced cells. Here, MTOR is linked to amyotrophic lateral sclerosis.