Remarkably, in a recent paper, S100A4 mRNA was identified together with other 333 transcripts, out of 22,977 annotated transcripts, among those whose stability is altered in C9orf72 ALS and sALS fibroblasts [65], sustaining our hypothesis that S100A4 dysregulation is a pathological hallmark of the disease shared by different cell types independently from their genetic variants and thus possibly reflecting a general reactive cellular state. The gene discussed is S100A4; the disease is amyotrophic lateral sclerosis.