S100A4 and amyotrophic lateral sclerosis: Niclosamide effects reside on its ability to target several signaling pathways, including S100A4, mammalian target of rapamycin (mTOR), signal transducer and activator of transcription 3 (STAT3), and nuclear factor-κB (NF-κB) [21, 49, 58, 70], which, interestingly, have been found to be dysregulated in ALS [32, 59, 69], suggesting its potential use to interfere with these altered mechanisms in the pathology.