Inflamed periodontal tissues produce various proinflammatory cytokines that participate in osteoclastogenesis and collagen degradation in periodontitis; these include interleukins (e.g., IL-1α, IL-1β, and IL-6), tumor necrosis factor-α, matrix metalloproteinases, and granulocyte colony-stimulating factor (G-CSF) [8, 9]. The gene discussed is CSF3; the disease is periodontitis.