INS and heart failure: Table 2 also displays that insulin users had significantly higher risks of MACE (aHR [95% CI]: 1.41 [1.23–1.62]), stroke (aHR [95% CI]: 1.31 [1.09–1.58]), ischemic heart disease (aHR [95% CI]: 1.36 [1.09–1.71]), and heart failure (aHR [95% CI]: 2.18 [1.70–2.80]) than nonusers.