FZD1 and nervous system disorder: The CpG most strongly driving this association was annotated to FZD1, a gene involved in the Wnt signaling pathway that (i) is essential for neurological development and the maintenance of the nervous system, and (ii) has been associated with susceptibility to neurological disorders (Okerlund and Cheyette, 2011; Patapoutian and Reichardt, 2000).