FEN1 and breast carcinoma: Moreover, Breast Cancer Gene Expression Miner v4.2 (bc-GenExMiner v4.2) data demonstrate that high FEN1 was significantly associated with increased probability of distant metastasis and shorter overall survival (p < 0.001, HR = 1.64, 95% CI = 1.50–1.81) (Fig. 1b, c respectively).