While DNA methylation alteration is frequently observed in NSCLC and plays a critical role in carcinogenesis, diagnosis and prediction,18, 19, 20 we also took advantage of publicly available databases such as Wanderer and MethSurv to investigate the methylation level of SHC1 and its clinical significance in LUAD and LUSC patients. Here, SHC1 is linked to non-small cell lung carcinoma.