Previous studies revealed that EGFR activation in NSCLC cells could release SHC‐binging protein 1 (SHCBP1) from SHC1, which subsequently transferred to the nucleus and advanced the trans‐activation of β‐catenin, thus leading to the development of stemness and malignant progression in NSCLC cells.55 The gene discussed is SHCBP1; the disease is non-small cell lung carcinoma.