BCL2 and colorectal carcinoma: As expected, all four tumor organoids were more sensitive to BCL-XL inhibition as the IC50s for A-1155463 were much lower than for ABT-199 and AZD5991 (Fig. 3e), confirming that classical CRC precursor and carcinoma lesions depend on BCL-XL for survival while BCL-2 and MCL1 remain nonessential in this context.