Intriguingly, BCL-XL inhibition was not effective on preexisting adenomas in this model (Supplementary Fig. 4c, d), which is likely due to the higher dose of A-1155463 needed to achieve the same level of apoptosis in fully transformed organoids (Supplementary Fig. 2b) in comparison to transforming organoids (Supplementary Fig. 4e). The gene discussed is BCL2L1; the disease is adenoma.