When cases were separated into DKK1 and FOXM1 positive expression (DKK1(+)/FOXM1(+)) group and others based on the top 80% of mRNA values of FOMX1 or DKK1, 117 of 174 pancreatic cancer cases (67.2%) were classified as DKK1(+)/FOXM1(+) group, of which positive ratio was similar to that of IHC study for DKK1 and FOXM1 (Fig. 6A), and 57 cases (32.8%) were classified as others (Fig. 6E). Here, DKK1 is linked to familial pancreatic carcinoma.