Standardized difference > 10% was observed for age, hypertension, dyslipidemia, obesity, nephropathy, eye diseases, diabetic polyneuropathy, stroke, ischemic heart disease, insulin, meglitinide, acarbose, calcium channel blockers, statins, fibrates, cancer, heart failure, Parkinson’s disease, dementia, valvular heart disease, pneumonia, liver cirrhosis and organ transplantation. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.