RAD50 and breast cancer: A non-significant excess of LoF variants were detected in the cases for RAD51D, BRIP1, BARD1 and MRE11A, and a statistically significant (unadjusted p < 0.05) excess of rare MS variants were identified in RAD51D and BRIP1. In contrast, there was no excess of variants in RAD50 and NBN which form the MRN complex with MRE11A; the LoF variant frequency in RAD50 and NBN was higher in the control group, indicating that, in the Australian population there is no evidence that these genes contribute to BC predisposition.