To gain insights into the pathomechanisms underlying BAG3P209L-induced cardiomyopathy, we generated transgenic mouse lines with CM-specific overexpression of either hBAG3WT-eGFP (αMHC-BAG3) or hBAG3P209L-eGFP (αMHC-BAG3P209L) (Supplementary Fig. 1a). This evidence concerns the gene BAG3 and cardiomyopathy.