Consistent with the physiological phenotype and transcript abundance data, also proteins involved in fibrotic pathways (Galectin-3) and associated with cardiomyopathies, the fetal cardiac gene program (LMNA, MYH7, NPPA) and vasopressin-regulated water reabsorption, as a sign of heart failure, were accumulating. The gene discussed is NPPA; the disease is cardiomyopathy.