The proteins identified in the equal loading TMT dataset cover almost 10,000 proteins over six orders of magnitude of summed peptide precursor intensities whereas the LFQ coverage limit is at about 1800 proteins, leaving many cancer-related proteins or oncogenes like the tumor suppressor p53 (TP53), oncogenic kinase BRAF and KEAP1 uncovered (Fig. 2c). This evidence concerns the gene BRAF and cancer.