Another important validation parameter was the coverage of relevant proteins for NSCLC (Supplementary Table 2), e.g., immunohistochemical markers, like cytokeratins (KRT5/6/7, immunohistochemistry (IHC) stainings for ADC/SCC shown in Supplementary Fig. 1A and B), the differentiation-determinant transcription factor TTF1 (NKX2-1), or the surfactant protein B processing aspartic protease Napsin A (NAPSA), and known signaling proteins like the oncogenic kinase EGFR, and members of the antioxidant response KEAP1-NRF2 pathway (CUL3). The gene discussed is CUL3; the disease is non-small cell lung carcinoma.