We therefore tested the usefulness of plasma Aβ42/Aβ40, P-tau217, and NfL (separately and combined) for predicting longitudinal cognitive decline and clinical outcomes in a CU population comprised of both cognitively normal (CN) healthy controls and individuals with subjective cognitive decline (SCD) who did not meet the diagnostic criteria for MCI. The gene discussed is NEFL; the disease is Schnyder corneal dystrophy.