Because IKZF1 is known to function as a transcriptional regressor of glucose and energy supply in synergy with other B-lymphoid transcription factors leading to the enforcement of a state of chronic energy deprivation, downregulation of IKZF1 activity generally leads to enhanced malignant characteristics requiring a higher energy state for proliferation and invasion in ALL cells29. The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.